System description from the Manual:
The crankshaft position (CKP) system variation learn feature is used to calculate reference period errors caused by slight tolerance variations in the crankshaft, and the CKP sensor. The calculated error allows the engine control module (ECM) to accurately compensate for reference period variations. This enhances the ability of the ECM to detect misfire events over a wider range of engine speed and load. The ECM stores the CKP system variation values after a learn procedure has been performed. If the actual CKP variation is not within the CKP system variation compensating values stored in the ECM, DTC P0300 may set.
Hope that helps.