Depends...I've seen people install Kicker Speakers in their front doors just by screwing them in. My Polk speakers have a smaller bolt circle than the size of the opening. And screws don't screw into air very well.

The Polk speakers I have came with an adapter ring that worked perfectly.
Rear crew cab speakers require special mounting. Either cut out the factory speaker from the plastic housing and secure the new speaker into that housing, or purchase/make a spacer no less than 1/2" thick. The rear housing will acommodate a standard 6.5" speakers without problem from what I've 'seen'. I did not tear apart my factory speaker to install my aftermarke ones.
so I was gonna buy a set of 4 --6.5in boss audio speakers. so I would have to mod them to fit in the rear of my club cab
If you mean Crew Cab a speaker will not simply fit in. If by club cab (that is not a GM term) you mean the suicide doors, then it's possible to fit them in place. The door panels are different.
I know this is way off topic from the OP, but I will post a picture of the install when I get home (if I remember).