All driveshafts that use U-joints have vibration issues since the joint cross rotates, but the caps also rock front to rear during operation, meaning the cap ends are forced to repeatedly accelerate and decelerate with every revolution. This is known as excitation torque, and eliminating vibrations and harmonics due to this phenomenon is the primary reason a driveshaft must be balanced. The issue you're going to have is that the longer the shaft is, the more pronounced these vibrations are near it's center, making it harder to balance it effectively enough to cancel vibrations from the u-joints. This is the primary reason auto makers go with a 2-piece driveshaft instead of longer shafts. A 2-piece shaft means that at some point, engineers decided it was impossible or too expensive to eliminate all of the vibrations while still using a one piece shaft.
If your truck has been lifted or lowered any, then it's likely that the u-joints operate in slightly different planes as well, further aggravating the issue.
You'd probably be fine, but figured it was worth mentioning. Nothing drives you nuts like a driveshaft vibration. Just something to think about.